The closest airport is Pescara, while Rome and Ancona airports are 2 hours drive away.
The esasiest is to fly (cheap!) with Ryanair from Londond Stanstead to Pescara. Flights are daily, and two hours in length. Visit http://www.ryanair.com/ to book.

Then rent a car - there are deals with Herts for Ryanair travellers but there are also several other car rental companies in Pescara airport.

After a 25-30 minutes drive you will be in the picturesque hills surrounding the beautiful small town of Loreto Aprutino. (But you can call it Loreto!) The key holder will meet you in Loreto and take you to the villa.